General Information

  • ID:  hor004516
  • Uniprot ID:  P33094
  • Protein name:  Somatostatin-28
  • Gene name:  SST
  • Organism:  Gallus gallus (Chicken)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0030334 regulation of cell migration
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  SANSNPALAPRERKAGCKNFFWKTFTSC
  • Length:  28(89-116)
  • Propeptide:  MLSCRLQCALALLSIALAVGTVSAAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPSQTENEALESEDLSRGAEQDEVRLELERSANSNPALAPRERKAGCKNFFWKTFTSC
  • Signal peptide:  MLSCRLQCALALLSIALAVGTVSA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibit the release of somatotropin
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  SSTR2, SSTR5
  • Target Unid:  Q58G84, F6RCI2
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  17-28
  • Structure ID:  AF-P33094-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004516_AF2.pdbhor004516_ESM.pdb

Physical Information

Mass: 361432 Formula: C138H211N41O39S2
Absent amino acids: DHIMQVY Common amino acids: A
pI: 10.51 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 9
Hydrophobicity: -66.43 Boman Index: -6163
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 28.21
Instability Index: 3003.93 Extinction Coefficient cystines: 5625
Absorbance 280nm: 208.33

Literature

  • PubMed ID:  NA
  • Title:  NA